The continued expansion of genomic sequence databases raises the possibility of prospectively identifying new such systems by computational mining.īy leveraging sequence repeats as an organizing principle, here we develop a systematic genome mining approach to explore new types of naturally adaptive systems, five of which are discussed in greater detail. Known examples of these systems, such as transcriptional activator-like effectors (TALE) and CRISPR, have been harnessed as powerful molecular tools with a wide range of applications including genome editing. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ĭepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Amino Acid Sequences Indicators Of Evolution Chapter 16 Lab How To Manage Yourīroad Institute of MIT and Harvard Cambridge, Cambridge, MA 02142, USA.ĭepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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